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Cyanoacrylate Versus Laser in the Treatment of Dentin Hypersensitivity

The aim of a non-inferiority trial is to demonstrate that the response to the investigational product is not clinically inferior to a comparative agent by more than a prespecified, small amount. This amount is known as the non-inferiority margin, or (D), and must be based on both statistical reasoning and clinical judgment. Thus, 15% was considered an adequate non-inferiority margin; in other words, the group treated with cyanoacrylate in the present study could have a performance£15% worse in reducing the mean DH value when compared to the group treated with laser. The results demonstrated non-inferiority of cyanoacrylate glue compared to laser and showed that there was no statistically significant difference between groups at the study endpoint. In the clinical trial of Gerschman et al.,9teethtreated with laser and subjected to the air-jet test showed a 67% reduction in sensitivity when comparing the scores obtained at baseline to those obtained at the final follow-up. In the present study, the results are similar, with a 68% reduction in sensitivity to the air jet between the baseline and final follow-up. Confirming the non-inferiority of cyanoacrylate glue compared to laser, the reduction in sensitivity observed in the cyanoacrylate group was 67% when the same parameters were compared. In tests with cold spray, the reduction in sensitivity was 39% and 40% in groups treated with laser and cyanoacrylate, respectively.

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